Challenges of designing trials for the primary prevention of stroke.
نویسنده
چکیده
BACKGROUND AND PURPOSE Prevention of a first stroke is an important strategy to reduce morbidity and mortality associated with cerebrovascular disease. In this discussion, we review challenges to development of clinical trials for prevention of a first stroke. Summary of Review- We discuss prevention of first stroke in the context of clinical trial design in the ARRIVE trial and a primary prevention trial in development for the elderly. CONCLUSIONS Stroke is an important outcome in cerebrovascular disease trials in the elderly, but it may be trumped by coronary heart disease as a more common end point.
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ورودعنوان ژورنال:
- Stroke
دوره 40 3 Suppl شماره
صفحات -
تاریخ انتشار 2009